教員・教室員について

  1. TOP
  2. 教員・教室員について
  3. 教員・教室員紹介
  4. 教員
  5. 関連分野／講座
  6. 前田 高宏（まえだ たかひろ）

プレシジョン医療学分野 教授

名前 前田 高宏（まえだ たかひろ）
卒業年 1994（平成6）年
学位取得年月 2002年3月 医学博士学位取得
専門領域 血液内科学
資格 日本内科学会認定内科医
所属学会 日本血液学会（評議員）、日本造血細胞移植学会、日本内科学会，日本癌学会，日本輸血・細胞治療学会、Society of Hematologic Oncology、American Society of Hematology

略歴

1994年～1998年

 JA愛知厚生連江南厚生病院　血液・腫瘍内科

1998年～1998年

 豊橋市民病院　血液・腫瘍内科

1998年～2001年

 名古屋大学医学部大学院、名古屋大学医学部付属病院

2001年～2005年

 Memorial Sloan-Kettering Cancer Center (Research fellow)

2006年～2011年

 City of Hope National Medical Center (Assistant professor)

2011年～2016年

 Brigham and Women's Hospotal・Division of Hematology, Harvard Medical School 
(Assistant professor), Broad institute (Associate member), Harvard Stem Cell Institute (Affiliated faculty),Dana-Farber/Harvard Cancer Center（Member）

2016年～2020年

 九州大学大学病院遺伝子・細胞療法部　准教授
2020年

九州大学医学部プレシジョン医療学分野　教授
現在に至る

代表的業績

  1. Maeda T et al. Up-regulation of costimulatory/adhesion molecules by histone deacetylase inhibitors in acute myeloid leukemia cells. Blood, 96(12): 3847-56, 2000.
  2. Ozawa Y et al. Histone deacetylase 3 associates with and represses the transcription factor GATA-2. Blood, 98(7): 2116-23, 2001.
  3. Maeda T et al. Role of the proto-oncogene pokemon in cellular transformation and ARF repression. Nature, 433: 278-285, 2005.
  4. Maeda T et al. Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Science, 316: 860-866, 2007.
  5. Maeda T et al. LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis. Dev. Cell, 17: 527-540, 2009.
  6. Sakurai et al. The LRF transcription factor regulates mature B cell development and the germinal center response in mice. J Clin Invest. , 121(7):2583-98, 2011.
  7. Tsuji K et al. Stage-specific functions of LRF in the transcriptional control of osteoclast development. Proc Natl Acad Sci USA, 14;109(7):2561-6, 2012.
  8. Zhang B et al. Altered microenvironmental niche regulation of leukemic and normal stem cells in chronic myelogenous leukemia. Cancer Cell, 21(4):577-92, 2012.
  9. Lee SU. LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance. Blood, 121(6):918-29, 2013.
  10. Chen C et al. Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metab., 17(3):343-52, 2013.
  11. Canver MC et al. Characterization of genomic deletion efficiency mediated by CRISPR/Cas9 in mammalian cells. J Biol Chem., 1;289(31):21312-24, 2013.
  12. Ishikawa Y et al. Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology. Haematologica, 100(4):439-51, 2014.
  13. Zhao Z et al. Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat Neurosci., 18(7):978-87, 2015.
  14. Norton LG et al. Notch Signal strength controls cell fate in the hemogenic endothelium. Nat Commun. Oct 14;6:8510, 2015.
  15. Canver MC et al. BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis. Nature, 527(7577):192-7, 2015.
  16. Masuda T et al. Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin. Science, 351(6270):285-9, 2016.
  17. Miyawaki K et al. Identification of unipotent megakaryocyte progenitors in human hematopoiesis. Blood. 2017 Mar 23. pii: blood-2016-09-741611.
  18. Chung J et al. Erythropoietin signaling regulates heme biosynthesis. Elife. 2017 May 29;6. pii: e24767.
  19. Yamauchi T et al. Genome-wide CRISPR-Cas9 screen identifies leukemia-specific dependence on a pre-mRNA metabolic pathway regulated by DCPS enzyme. Cancer Cell. 2018 Feb 8. pii: S1535-6108(18)30012-6.
  20.  Sugio T et al. Microenvironmental immune cell signatures dictate clinical outcomes for PTCL-NOS. Blood Advances, Sep 11;2(17):2242-2252.
  21. Schoonenberg V.A.C.et al. CRISPRO: identification of functional protein coding sequences based on genome editing dense mutagenesis. Genome Biology, 2018 Oct 19;19(1):169. doi: 10.1186/s13059-018-1563-5. 
  22. Canver M.C. et al. DrugThatGene: integrative analysis to streamline the identification of druggable genes, pathways, and protein complexes from CRISPR screens. Bioinformatics, 2018 Nov 5. doi: 10.1093/bioinformatics/bty913
  23. Sher F. et al. Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis. Nat Genet. In press.

一覧