教員・教室員について

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  2. 教員・教室員について
  3. 教員・教室員紹介
  4. 教員
  5. 第一内科
  6. 赤司 浩一（あかし こういち）

教授

研究教育活動

名前 赤司 浩一（あかし こういち）
卒業年 1985（昭和60）年
学位取得年月 1993年2月　医学博士学位取得
専門領域 血液内科学、免疫学、幹細胞学
資格 日本内科学会認定内科医・総合内科専門医
所属学会 日本血液学会（理事長），日本内科学会（評議員），
日本造血細胞移植学会（評議員），日本免疫学会，
日本癌学会（評議員），米国血液学会（Editorial Board），
国際実験血液学会（Editorial Board）

略歴

1985年~1993年

 九州大学医学部第一内科，九州大学病院輸血部，九州厚生年金病院，
原三信会病院勤務

1993年

 スタンフォード大学・病理発生学　(Weissman IL研)　研究員

2000年

 ハーバード大学・ダナ・ファーバー癌研究所・ 腫瘍免疫エイズ学講座・助教授(Assistant professor)

2004年

 同・準教授(Associate professor)

2004年

 九州大学病院・遺伝子細胞療法部・教授

2008年

 九州大学大学院 病態修復内科学 教授
2018年

九州大学病院　病院長
2023年

九州大学　医学部長
現在に至る

代表的業績

  1. Akashi K, et al. Interleukin-4 suppresses the spontaneous growth of chronic myelomonocytic leukemia cells.
    J Clin Invest 1991; 88: 223-30 .
  2. Akashi K, et al. Effects of interleukin-4 and interleukin-6 on the proliferation of CD34+ an d CD34¯blasts from acute myelogenous leukemia.
    Blood 1991; 78: 197-204.
  3. Akashi K, et al. Severe infectious mononucleosis-like syndrome and a primary human herpesvirus-6 infection in an adult.
    N Engl J Med 1993; 329: 168-171.
  4. Morrison S, et al. The aging of hemetopoietic stem cell.
    Nat Med 1996; 2: 1011-1016
  5. Akashi K, et al. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice.
    Cell 1997; 89: 1033-1041.
  6. Kondo M, et al. Bcl-2 rescues T lymphopoiesis but not B or NK cell development in common cytokine receptor &g chain-deficient mice.
    Immunity 1997; 7: 155-162.
  7. Kondo M, et al. Identification of clonogenic common lymphoid progenitors in mouse bone marrow.
    Cell 1997; 91: 661-672.
  8. Akashi K, et al. Two distinct pathway of positive selection for thymocytes.
    Proc Natl Acad Sci USA 1998; 95: 2486-2491.
  9. Akashi K, et al. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages.
    Nature 2000; 404: 193-197.
  10. Akashi K, et al. B lymphopoiesis in the thymus.
    J Immunol 2000; 164: 5221-5226.
  11. Traver D, et al. Development of CD8&a-positive dendritic cells from a common myeloid progenitor.
    Science 2000; 290: 2152-2154. (Equal contribution).
  12. Kondo M, et al. Cell fate conversion of lymphoid committed progenitors by instructive actions of cytokines.
    Nature 2000; 407: 383-386.
  13. Nakorn T, et al. Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S.
    J Clin Invest 2002; 109: 1579-85.
  14. Akashi K, et al. Transcriptional accessibility for multi-tissue and multi-hematopoietic lineage genes is hierarchically controlled during early hematopoiesis.
    Blood 2003; 101: 383-390.
  15. Iwasaki-Arai J, et al. Enforced GM-CSF signals in lymphoid-committed progenitors do not support lymphoid development, but instruct lymphoid to myelomonocytic lineage conversion.
    J Exp Med 2003; 197: 1311-1312.
  16. Huntly BJP, et al. MOZ-TIF2 but not BCR-ABL confers properties of leukaemic stem cells to committed murine hematopoietic progenitors.
    Cancer Cell 2004; 6: 587-596.
  17. Zhang P, et al. Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP.
    Immunity 2004; 21: 853-863.
  18. Rosenbauer F, et al. Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.
    Nat Genet 2004; 36: 624-30.
  19. Kozar K, et al. Mouse development and cell proliferation in the absence of D-cyclins.
    Cell 2004; 118: 477-49.
  20. Opferman JT, et al. Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.
    Science 2005; 307: 1101-1104.
  21. Akashi K, et al. The complex cartography of stem cell commitment.
    Cell 2005; 121: 160-162.
  22. Rosenbauer F, et al. Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1.
    Nat Genet 2006; 38: 27-37.
  23. Hirai H, et al. C/EBPbeta is required for ‘emergency’ granulopoiesis.
    Nat Immunol 2006; 7: 732-739.
  24. Cantor AB, et al. Antagonism of FOG-1 and GATA foctors in fate choice for the mast cell lineage.
    J Exp Med 2008; 205: 611-624.
  25. Kalaszczynska I, et al. Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells.
    Cell 2009; 23: 352-65.
  26. Mori Y, et al. Identification of the human eosinophil lineage-committed progenitor: revision of phenotypic definition of the human common myeloid progenitor.
    J Exp Med 2009; 206: 183-93.
  27. Kikushige Y, et al. TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cells.
    Cell Stem Cell 2010; 7: 708-717.
  28. Takashima S, et al. The Wnt agonist R-spondin 1 regulates systemic graft-versus-host disease by protecting intestinal stem cells.
    J Exp Med 2011; 208: 285-294.
  29. Kikushige Y, et al. Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia.
    Cancer Cell 2011; 20: 246-259.
  30. Niiro H, et al.CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells.
    Blood 119: 2263-2273, 2012
  31. Kuriyama T,et al.Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis.
    Blood 120: 4058-4067, 2012
  32. Shima T,et al.Quantitation of hematogones at the time of engraftment is a useful prognostic indicator in allogeneic hematopoietic stem cell transplantation.
    Blood 121: 840-848, 2013
  33. Yamauchi T, et al.Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment.
    Blood 121: 1316-1325, 2013
  34. Yonekawa A,et al.Dectin-2 Is a Direct Receptor for Mannose-Capped Lipoarabinomannan of Mycobacteria.
    Immunity 41: 402-413, 2014
  35. Miyawaki K, et al.CD41 marks the initial myelo-erythroid lineage specification in adult mouse hematopoiesis: Redefinition of murine common myeloid progenitor.
    Stem Cells 33: 976-987, 2014
  36. Izumi K,et al.Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes.
    Nat Commun 6: 6748, 2015
  37. Shimoda S,et al.Natural killer cells regulate T cell immune responses in primary biliary cirrhosis.
    Hepatology 62: 1817-1827, 2015
  38. Kikushige Y,et al.A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression.
    Cell Stem Cell 17: 341-352, 2015
  39. Miyawaki K, Iwasaki H, Jiromaru T, Kusumoto H, Yurino A, Sugio T, Uehara Y, Odawara J, Daitoku S, Kunisaki Y, Mori Y, Arinobu Y, Tsuzuki H, Kikushige Y, Iino T, Kato K, Takenaka K, Miyamoto T, Maeda T, Akashi K. Identification of unipotent megakaryocyte progenitors in human hematopoiesis. Blood. 129: 3332-3343, 2017
  40. Shimoji S, Hashimoto D, Tsujigiwa H, Miyawaki K, Kato K, Takahashi S, Ogasawara R, Jiromaru T, Iwasaki H, Miyamoto T, Akashi K, Teshima T. Graft-versus-host disease targets ovary and causes female infertility in mice. Blood. 129: 1216-1225, 2017

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