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2011年
Kikushige Y, Ishikawa F, Miyamoto T, Shima T, Urata S, Yoshimoto G, Mori Y, Iino T, Yamauchi T, Eto T, Niiro H, Iwasaki H, Takenaka K, Akashi K.
Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia.
Cancer Cell. 2011 Aug 16;20(2):246-59.
Takashima S, Kadowaki M, Aoyama K, Koyama M, Oshima T, Tomizuka K, Akashi K, Teshima T.
The Wnt agonist R-spondin1 regulates systemic graft-versus-host disease by protecting intestinal stem cells.
J Exp Med. 2011 Feb 14;208(2):285-94.
Hashimoto D, Chow A, Greter M, Saenger Y, Kwan WH, Leboeuf M, Ginhoux F, Ochando JC, Kunisaki Y, van Rooijen N, Liu C, Teshima T, Heeger PS, Stanley ER, Frenette PS, Merad M.
Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation.
J Exp Med. 2011 May 9;208(5):1069-82.
Eppert K, Takenaka K, Lechman ER, Waldron L, Nilsson B, van Galen P, Metzeler KH, Poeppl A, Ling V, Beyene J, Canty AJ, Danska JS, Bohlander SK, Buske C, Minden MD, Golub TR, Jurisica I, Ebert BL, Dick JE.
Stem cell gene expression programs influence clinical outcome in human leukemia.
Nat Med. 2011 Aug 28. doi: 10.1038/nm.2415. [Epub ahead of print]
2010年
Kikushige Y, Shima T, Takayanagi S, Urata S, Miyamoto T, Iwasaki H, Takenaka K, Teshima T, Tanaka T, Inagaki Y, Akashi K.
TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cells.
Cell Stem Cell. 2010 Dec 3;7(6):708-17.
Asakura S, Hashimoto D, Takashima S, Sugiyama H, Maeda Y, Akashi K, Tanimoto M, Teshima T.
Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice.
J Clin Invest. 2010 Jul 1;120(7):2370-8.
2009年
Kalaszczynska I, Geng Y, Iino T, Mizuno S, Choi Y, Kondratiuk I, Silver DP, Wolgemuth DJ, Akashi K, Sicinski P.
Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells.
Cell. 2009 Jul 23;138(2):352-65.
Mori Y, Iwasaki H, Kohno K, Yoshimoto G, Kikushige Y, Okeda A, Uike N, Niiro H, Takenaka K, Nagafuji K, Miyamoto T, Harada M, Takatsu K, Akashi K.
Identification of the human eosinophil lineage-committed progenitor: revision of phenotypic definition of the human common myeloid progenitor.
J Exp Med. 2009 Jan 16;206(1):183-93.
Ozaki K, Sato H, Inoue K, Tsunoda T, Sakata Y, Mizuno H, Lin TH, Miyamoto Y, Aoki A, Onouchi Y, Sheu SH, Ikegawa S, Odashiro K, Nobuyoshi M, Juo SH, Hori M, Nakamura Y, Tanaka T.
SNPs in BRAP associated with risk of myocardial infarction in Asian populations.
Nat Genet. 2009 Mar;41(3):329-33.
2008年
Cantor AB, Iwasaki H, Arinobu Y, Moran TB, Shigematsu H, Sullivan MR, Akashi K, Orkin SH.
Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage.
J Exp Med. 2008 Mar 17;205(3):611-24.
2007年
Ishikawa F, Yoshida S, Saito Y, Hijikata A, Kitamura H, Tanaka S, Nakamura R, Tanaka T, Tomiyama H, Saito N, Fukata M, Miyamoto T, Lyons B, Ohshima K, Uchida N, Taniguchi S, Ohara O, Akashi K, Harada M, Shultz LD.
Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region.
Nat Biotechnol. 2007 Nov;25(11):1315-21.
Takenaka K, Prasolava TK, Wang JC, Mortin-Toth SM, Khalouei S, Gan OI, Dick JE, Danska JS.
Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells.
Nat Immunol. 2007 Dec;8(12):1313-23.
Myeloid lineage commitment from the hematopoietic stem cell.
Immunity. 2007 Jun;26(6):726-40.
Arinobu Y, Mizuno S, Chong Y, Shigematsu H, Iino T, Iwasaki H, Graf T, Mayfield R, Chan S, Kastner P, Akashi K.
Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages.
Cell Stem Cell. 2007 Oct 11;1(4):416-27.
2006年
Iwasaki H, Mizuno S, Arinobu Y, Ozawa H, Mori Y, Shigematsu H, Takatsu K, Tenen DG, Akashi K.
The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages.
Genes Dev. 2006 Nov 1;20(21):3010-21.
Rosenbauer F, Owens BM, Yu L, Tumang JR, Steidl U, Kutok JL, Clayton LK, Wagner K, Scheller M, Iwasaki H, Liu C, Hackanson B, Akashi K, Leutz A, Rothstein TL, Plass C, Tenen DG.
Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1.
Nat Genet. 2006 Jan;38(1):27-37.
Hirai H, Zhang P, Dayaram T, Hetherington CJ, Mizuno S, Imanishi J, Akashi K, Tenen DG.
C/EBPbeta is required for 'emergency' granulopoiesis.
Nat Immunol. 2006 Jul;7(7):732-9.
Shimoda S, Ishikawa F, Kamihira T, Komori A, Niiro H, Baba E, Harada K, Isse K, Nakanuma Y, Ishibashi H, Gershwin ME, Harada M.
Autoreactive T-cell responses in primary biliary cirrhosis are proinflammatory whereas those of controls are regulatory.
Gastroenterology. 2006 Aug;131(2):606-18.
Thymus exclusivity: all the right conditions for T cells.
Immunity. 2006 Nov;25(5):697-700.
2005年
The complex cartography of stem cell commitment.
Cell. 2005 Apr 22;121(2):160-2.
Mitoma H, Horiuchi T, Hatta N, Tsukamoto H, Harashima S, Kikuchi Y, Otsuka J, Okamura S, Fujita S, Harada M.
Infliximab induces potent anti-inflammatory responses by outside-to-inside signals through transmembrane TNF-alpha.
Gastroenterology. 2005 Feb;128(2):376-92.
Iwasaki H, Mizuno S, Mayfield R, Shigematsu H, Arinobu Y, Seed B, Gurish MF, Takatsu K, Akashi K.
Identification of eosinophil lineage-committed progenitors in the murine bone marrow.
J Exp Med. 2005 Jun 20;201(12):1891-7.
Opferman JT, Iwasaki H, Ong CC, Suh H, Mizuno S, Akashi K, Korsmeyer SJ.
Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.
Science. 2005 Feb 18;307(5712):1101-4.
Arinobu Y, Iwasaki H, Gurish MF, Mizuno S, Shigematsu H, Ozawa H, Tenen DG, Austen KF, Akashi K.
Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis.
Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18105-10.
2004年
Huntly BJ, Shigematsu H, Deguchi K, Lee BH, Mizuno S, Duclos N, Rowan R, Amaral S, Curley D, Williams IR, Akashi K, Gilliland DG.
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.
Cancer Cell. 2004 Dec;6(6):587-96.
Rosenbauer F, Wagner K, Kutok JL, Iwasaki H, Le Beau MM, Okuno Y, Akashi K, Fiering S, Tenen DG.
Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.
Nat Genet. 2004 Jun;36(6):624-30.
Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, Sicinska E, Geng Y, Yu Q, Bhattacharya S, Bronson RT, Akashi K, Sicinski P.
Mouse development and cell proliferation in the absence of D-cyclins.
Cell. 2004 Aug 20;118(4):477-91.
Ozaki K, Inoue K, Sato H, Iida A, Ohnishi Y, Sekine A, Sato H, Odashiro K, Nobuyoshi M, Hori M, Nakamura Y, Tanaka T.
Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro.
Nature. 2004 May 6;429(6987):72-5.
Zhang P, Iwasaki-Arai J, Iwasaki H, Fenyus ML, Dayaram T, Owens BM, Shigematsu H, Levantini E, Huettner CS, Lekstrom-Himes JA, Akashi K, Tenen DG.
Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha.
Immunity. 2004 Dec;21(6):853-63.
Shigematsu H, Reizis B, Iwasaki H, Mizuno S, Hu D, Traver D, Leder P, Sakaguchi N, Akashi K.
Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin.
Immunity. 2004 Jul;21(1):43-53.
2003年
Iwasaki-Arai J, Iwasaki H, Miyamoto T, Watanabe S, Akashi K.
Enforced granulocyte/macrophage colony-stimulating factor signals do not support lymphopoiesis, but instruct lymphoid to myelomonocytic lineage conversion.
J Exp Med. 2003 May 19;197(10):1311-22.
Nakorn TN, Miyamoto T, Weissman IL.
Characterization of mouse clonogenic megakaryocyte progenitors.
Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):205-10.
Kamihira T, Shimoda S, Harada K, Kawano A, Handa M, Baba E, Tsuneyama K, Nakamura M, Ishibashi H, Nakanuma Y, Gershwin ME, Harada M.
Distinct costimulation dependent and independent autoreactive T-cell clones in primary biliary cirrhosis.
Gastroenterology. 2003 Nov;125(5):1379-87.
Shimoda S, Nakamura M, Ishibashi H, Kawano A, Kamihira T, Sakamoto N, Matsushita S, Tanaka A, Worman HJ, Gershwin ME, Harada M.
Molecular mimicry of mitochondrial and nuclear autoantigens in primary biliary cirrhosis.
Gastroenterology. 2003 Jun;124(7):1915-25.
Ye M, Iwasaki H, Laiosa CV, Stadtfeld M, Xie H, Heck S, Clausen B, Akashi K, Graf T.
Hematopoietic stem cells expressing the myeloid lysozyme gene retain long-term, multilineage repopulation potential.
Immunity. 2003 Nov;19(5):689-99.
Iwasaki H, Mizuno S, Wells RA, Cantor AB, Watanabe S, Akashi K.
GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/erythrocyte lineages.
Immunity. 2003 Sep;19(3):451-62.
2002年
Na Nakorn T, Traver D, Weissman IL, Akashi K.
Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S.
J Clin Invest. 2002 Jun;109(12):1579-85.
Miyamoto T, Iwasaki H, Reizis B, Ye M, Graf T, Weissman IL, Akashi K.
Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment.
Dev Cell. 2002 Jul;3(1):137-47.
Manz MG, Miyamoto T, Akashi K, Weissman IL.
Prospective isolation of human clonogenic common myeloid progenitors.
Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11872-7.
Niiro H, Maeda A, Kurosaki T, Clark EA.
The B lymphocyte adaptor molecule of 32 kD (Bam32) regulates B cell antigen receptor signaling and cell survival.
J Exp Med. 2002 Jan 7;195(1):143-9.
Regulation of B-cell fate by antigen-receptor signals.
Nat Rev Immunol. 2002 Dec;2(12):945-56.
Teshima T, Ordemann R, Reddy P, Gagin S, Liu C, Cooke KR, Ferrara JL.
Acute graft-versus-host disease does not require alloantigen expression on host epithelium.
Nat Med. 2002 Jun;8(6):575-81.
Ordemann R, Hutchinson R, Friedman J, Burakoff SJ, Reddy P, Duffner U, Braun TM, Liu C, Teshima T, Ferrara JL.
Enhanced allostimulatory activity of host antigen-presenting cells in old mice intensifies acute graft-versus-host disease.
J Clin Invest. 2002 May;109(9):1249-56.
2001年
Yasutomo K, Horiuchi T, Kagami S, Tsukamoto H, Hashimura C, Urushihara M, Kuroda Y.
Mutation of DNASE1 in people with systemic lupus erythematosus.
Nat Genet. 2001 Aug;28(4):313-4.
Yuan Y, Zhou L, Miyamoto T, Iwasaki H, Harakawa N, Hetherington CJ, Burel SA, Lagasse E, Weissman IL, Akashi K, Zhang DE.
AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations.
Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10398-403.
Reddy P, Teshima T, Kukuruga M, Ordemann R, Liu C, Lowler K, Ferrara JL.
Interleukin-18 regulates acute graft-versus-host disease by enhancing Fas-mediated donor T cell apoptosis.
J Exp Med. 2001 Nov 19;194(10):1433-40.
Cooke KR, Gerbitz A, Crawford JM, Teshima T, Hill GR, Tesolin A, Rossignol DP, Ferrara JL.
LPS antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantation.
J Clin Invest. 2001 Jun;107(12):1581-9.
2000年
Akashi K, Traver D, Miyamoto T, Weissman IL.
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages.
Nature. 2000 Mar 9;404(6774):193-7.
Traver D, Akashi K, Manz M, Merad M, Miyamoto T, Engleman EG, Weissman IL.
Development of CD8alpha-positive dendritic cells from a common myeloid progenitor.
Science. 2000 Dec 15;290(5499):2152-4.
Kondo M, Scherer DC, Miyamoto T, King AG, Akashi K, Sugamura K, Weissman IL.
Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines.
Nature. 2000 Sep 21;407(6802):383-6.
Miyamoto T, Weissman IL, Akashi K.
AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation.
Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7521-6.
Marshall AJ, Niiro H, Lerner CG, Yun TJ, Thomas S, Disteche CM, Clark EA.
A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase.
J Exp Med. 2000 Apr 17;191(8):1319-32.
Shimoda K, Kato K, Aoki K, Matsuda T, Miyamoto A, Shibamori M, Yamashita M, Numata A, Takase K, Kobayashi S, Shibata S, Asano Y, Gondo H, Sekiguchi K, Nakayama K, Nakayama T, Okamura T, Okamura S, Niho Y, Nakayama K.
Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function.
Immunity. 2000 Oct;13(4):561-71.
1999年
Davis DM, Mandelboim O, Luque I, Baba E, Boyson J, Strominger JL.
The transmembrane sequence of human histocompatibility leukocyte antigen (HLA)-C as a determinant in inhibition of a subset of natural killer cells.
J Exp Med. 1999 Apr 19;189(8):1265-74.
Teshima T, Hill GR, Pan L, Brinson YS, van den Brink MR, Cooke KR, Ferrara JL.
IL-11 separates graft-versus-leukemia effects from graft-versus-host disease after bone marrow transplantation.
J Clin Invest. 1999 Aug;104(3):317-25.
Hill GR, Teshima T, Gerbitz A, Pan L, Cooke KR, Brinson YS, Crawford JM, Ferrara JL.
Differential roles of IL-1 and TNF-alpha on graft-versus-host disease and graft versus leukemia.
J Clin Invest. 1999 Aug;104(4):459-67.
1998年
Akashi K, Kondo M, Weissman IL.
Two distinct pathways of positive selection for thymocytes.
Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2486-91.
Shimoda S, Van de Water J, Ansari A, Nakamura M, Ishibashi H, Coppel RL, Lake J, Keeffe EB, Roche TE, Gershwin ME.
Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis.
J Clin Invest. 1998 Nov 15;102(10):1831-40.
Hill GR, Cooke KR, Teshima T, Crawford JM, Keith JC Jr, Brinson YS, Bungard D, Ferrara JL.
Interleukin-11 promotes T cell polarization and prevents acute graft-versus-host disease after allogeneic bone marrow transplantation.
J Clin Invest. 1998 Jul 1;102(1):115-23.
Mitsuyasu H, Izuhara K, Mao XQ, Gao PS, Arinobu Y, Enomoto T, Kawai M, Sasaki S, Dake Y, Hamasaki N, Shirakawa T, Hopkin JM.
Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma.
Nat Genet. 1998 Jun;19(2):119-20.
1997年
Akashi K, Kondo M, von Freeden-Jeffry U, Murray R, Weissman IL.
Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice.
Cell. 1997 Jun 27;89(7):1033-41.
Kondo M, Akashi K, Domen J, Sugamura K, Weissman IL.
Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice.
Immunity. 1997 Jul;7(1):155-62.
Kondo M, Weissman IL, Akashi K.
Identification of clonogenic common lymphoid progenitors in mouse bone marrow.
Cell. 1997 Nov 28;91(5):661-72.
1996年
Morrison SJ, Wandycz AM, Akashi K, Globerson A, Weissman IL.
The aging of hematopoietic stem cells.
Nat Med. 1996 Sep;2(9):1011-6.
Shimoda K, van Deursen J, Sangster MY, Sarawar SR, Carson RT, Tripp RA, Chu C, Quelle FW, Nosaka T, Vignali DA, Doherty PC, Grosveld G, Paul WE, Ihle JN.
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene.
Nature. 1996 Apr 18;380(6575):630-3.
1995年
Shimoda S, Nakamura M, Ishibashi H, Hayashida K, Niho Y.
HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: evidence of molecular mimicry in human autoimmune diseases.
J Exp Med. 1995 May 1;181(5):1835-45.
1993年
Mizuno S, Akashi K, Hirota Y, Gyoten S, Matsumoto I, Harada M, Niho Y.
Filgrastim treatment of leukaemic transformation in myelodysplastic syndrome.
Lancet. 1993 Jun 5;341(8858):1475-6.
Shimoda K, Okamura S, Harada N, Kondo S, Okamura T, Niho Y.
Identification of a functional receptor for granulocyte colony-stimulating factor on platelets.
J Clin Invest. 1993 Apr;91(4):1310-3.
Shimoda K, Okamura S, Inaba S, Okamura T, Ohga S, Ueda K, Niho Y.
Granulocyte colony-stimulating factor and platelet aggregation.
Lancet. 1993 Mar 6;341(8845):633.
Akashi K, Eizuru Y, Sumiyoshi Y, Minematsu T, Hara S, Harada M, Kikuchi M, Niho Y, Minamishima Y.
severe infectious mononucleosis-like syndrome and primary human herpesvirus 6 infection in an adult.
N Engl J Med. 1993 Jul 15;329(3):168-71.
1992年
Kamura T, Okamura T, Murakawa M, Tsuda H, Teshima T, Shibuya T, Harada M, Niho Y.
Deficiency of coagulation factor XIII A subunit caused by the dinucleotide deletion at the 5' end of exon III.
J Clin Invest. 1992 Aug;90(2):315-9.
