九州大学医学部 第一内科

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九州大学医学部第一内科教室

〒812-8582 福岡市東区馬出3-1-1
[TEL] 092-642-5228
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第一内科について

> ホーム> 第一内科について SELECTED PAPERS (Impact Factor>10) | 論文リスト

論文リスト

  • SELECTED PAPERS (Impact Factor>10)
  • ALL List (過去5年間)
  • Citation Index >150

2016年

Masuda T, Wang X, Maeda M, Canver MC, Sher F, Funnell AP, Fisher C, Suciu M, Martyn GE, Norton LJ, Zhu C, Kurita R, Nakamura Y, Xu J, Higgs DR, Crossley M, Bauer DE, Orkin SH, Maeda Τ.Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.Science 351(6270): 285-289,2016


Khan JA, Mendelson A, Kunisaki Y, Birbrair A, Kou Y, Arnal-Estapé A, Pinho S, Ciero P, Nakahara F, Ma'ayan A, Bergman A, Merad M, Frenette PS.Fetal liver hematopoietic stem cell niches associate with portal vessels.Science 351:176-180,2016


Fuji S, Inoue Y, Utsunomiya A, Moriuchi Y, Uchimaru K, Choi I, Otsuka E, Henzan H, Kato K, Tomoyose T, Yamamoto H.Pretransplant anti-CCR4 antibody mogamulizumab against ATLL is associated with significantly increased risks of severe and steroid-refractory GVHD, non-relapse mortality and overall mortality.J Clin Oncol 34:3426-3433,2016


Miyoshi H, Kiyasu J, Kato T, Yoshida N, Shimono J, Yokoyama S, Taniguchi H, Sasaki Y, Kurita D, Kawamoto K, Kato K, Imaizumi Y, Seto M, Ohshima K.PD-L1 expression on neoplastic or stromal cell is respectively poor or good prognostic factor for adult T-cell.Blood 128:1374-1381,2016


Bararia D, Kwok HS, Welner RS, Numata A, Sárosi MB, Yang H, Wee S, Tschuri S, Ray D, Weigert O, Levantini E, Ebralidze AK, Gunaratne J, Tenen DG.Acetylation of C/EBPα inhibits its granulopoietic function.Nat Commun 7:10968,2016


2015年

Zhang D, Chen G, Manwani D, Mortha A, Xu C, Faith JJ, Burk RD, Kunisaki Y, Jang JE, Scheiermann C, Merad M, Frenette PS.Neutrophil ageing is regulated by the microbiome. Nature 525:528-32,2015.


Hayakawa Y, Ariyama H, Stancikova J, Sakitani K, Asfaha S, Renz BW, Dubeykovskaya ZA, Shibata W, Wang H, Westphalen CB, Chen X, Takemoto Y, Kim W, Khurana SS, Tailor Y, Nagar K, Tomita H, Hara A, Sepulveda AR, Setlik W, Gershon MD, Saha S, Ding L, Shen Z, Fox JG, Friedman RA, Konieczny SF, Worthley DL, Korinek V, Wang TC.Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche. Cancer Cell 28:800-14,2015.


Kikushige Y, Miyamoto T, Yuda J, Jabbarzadeh-Tabrizi S, Shima T, Takayanagi S, Niiro H, Yurino A, Miyawaki K, Takenaka K, Iwasaki H, Akashi K.A TIM-3/Gal-9 autocrine stimulatory loop drives self-renewal of human myeloid leukemia stem cells and leukemic progression. Cell Stem Cell 17:341-52,2015.


Okugawa Y, Toiyama Y, Toden S, Mitoma H, Nagasaka T, Tanaka K, Inoue Y, Kusunoki M, Boland CR, Goel A.Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer. Gut 2015.


Hayakawa Y, Jin G, Wang H, Chen X, Westphalen CB, Asfaha S, Renz BW, Ariyama H, Dubeykovskaya ZA, Takemoto Y, Lee Y, Muley A, Tailor Y, Chen D, Muthupalani S, Fox JG, Shulkes A, Worthley DL, Takaishi S, Wang TC.CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis. Gut 64:544-53,2015.


Shimoda S, Hisamoto S, Harada K, Iwasaka S, Chong Y, Nakamura M, Bekki Y, Yoshizumi T, Shirabe K, Ikegami T, Maehara Y, He XS, Gershwin ME, Akashi K.Natural killer cells regulate T cell immune responses in primary biliary cirrhosis. Hepatology 62:1817-27,2015.


Izumi K, Mine K, Inoue Y, Teshima M, Ogawa S, Kai K, Kurafuji T, Hirakawa K, Miyakawa D, Ikeda H, Inada A, Hara M, Yamada H, Akashi K, Niho Y, Ina K, Kobayashi T, Yoshikai Y, Anzai K, Yamashita T, Minagawa H, Fujimoto S, Kurisaki H, Shimoda K, Katsuta H, Nagafuchi S.Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes. Nat Commun 6:6748,2015.


Nonami A, Sattler M, Weisberg E, Liu Q, Zhang J, Patricelli MP, Yoon H, Christie AL, Sauer AM, Kohl NE, Kung AL, Sim T, Gray NS, and Griffin JD.Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacological approach. Blood 125:3133-43,2015.


Uryu H, Hashimoto D, Kato K, Hayase E, Matsuoka S, Ogasawara R, Takahashi S, Maeda Y, Iwasaki H, Miyamoto T, Saijo S, Iwakura Y, Hill GR, Akashi K, Teshima T.α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice. Blood 125:3014-23,2015.


Weisberg E*, Nonami A*, Liu Q, Chen Z, Nelson E, Liu F, Zhang J, Sattler M, Wong KK, Gray NS, Griffin JD.Identification of Wee1 as a novel therapeutic target for mutant Ras-driven malignancies. Leukemia 29:27-37,2015.


2014年

Damm, F., E. Mylonas, A. Cosson, K. Yoshida, V. Della Valle, E. Mouly, M. Diop, L. Scourzic, Y. Shiraishi, K. Chiba, H. Tanaka, S. Miyano, Y. Kikushige, F. Davi, J. Lambert, D. Gautheret, H. Merle-Beral, L. Sutton, P. Dessen, E. Solary, K. Akashi, W. Vainchenker, T. Mercher, N. Droin, S. Ogawa, F. Nguyen-Khac & O. A. Bernard;Acquired initiating mutations in early hematopoietic cells of CLL patients. Cancer Discovery 4:1088-101,2014.


Ogura M, Ishida T, Hatake K, Taniwaki M, Ando K, Tobinai K, Fujimoto K, Yamamoto K, Miyamoto T, Uike N, Tanimoto M, Tsukasaki K, Ishizawa K, Suzumiya J, Inagaki H, Tamura K, Akinaga S, Tomonaga M, Ueda R.Multicenter phase II study of Mogamulizumab (KW-0761), a defucosylated anti-CC chemokine receptor 4 antibody, in patients with relapsed peripheral T-cell lymphoma and cutaneous T-cell lymphoma. J Clin Oncol 32:1157-63,2014.


Ehara N, Ando K, Furukawa Y, Inoue K, Fujii S, Shizuta S, Kimura T, Arita T, Nobuyoshi M, Isshiki T.Long-term clinical outcomes of upgrading from chronic right ventricular pacing to cardiac resynchronization therapy in patients with heart failure. Eur Heart J 35:356,2014.


Mizoguchi T, Pinho S, Ahmed J, Kunisaki Y, Hanoun M, Mendelson A, Ono N, Kronenberg HM, Frenette PS.Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development. Developmental Cell 29:340-9,2014.


Sha W, Mitoma H, Hanabuchi S, Bao M, Weng L, Sugimoto N, Liu Y, Zhang Z, Zhong J, Sun B, Liu YJ.Human NLRP3 inflammasome senses multiple types of bacterial RNAs. Proc Natl Acad Sci USA 111:16059-64,2014.


Sugimoto, N., Mitoma, H., Kim, T., Hanabuchi, S., and Liu, Y.J.Helicase proteins DHX29 and RIG-I cosense cytosolic nucleic acids in the human airway system. Proc Natl Acad Sci USA .111:7747-52,2014.


Placke T, Faber K, Nonami A, Heidel FH, Kindler T, Krämer A, Salih HR, Stephen M. Sykes, William C. Hahn, Michael D. Milsom, Claudia Scholl, and Stefan Fröhling.Requirement for CDK6 in MLL-Rearranged Acute Myeloid Leukemia. Blood 124:13-23,2014.


Nobusue H, Onishi N, Shimizu T, Sugihara E, Oki Y, Sumikawa Y, Chiyoda T, Akashi K, Saya H, Kano K.Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation. Nat Commun 5:3368,2014.


2013年

Yamauchi T, Takenaka K, Urata S, Shima T, Kikushige Y, Tokuyama T, Iwamoto C, Nishihara M, Iwasaki H, Miyamoto T, Honma N, Nakao M, Matozaki T, Akashi K.Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment. Blood 121:1316-25,2013.


Shima T, Miyamoto T, Kikushige Y, Mori Y, Kamezaki K, Takase K, Henzan H, Numata A, Ito Y, Takenaka K, Iwasaki H, Kamimura T, Eto T, Nagafuji K, Teshima T, Kato K, Akashi K.Quantitation of hematogones at the time of engraftment is a useful prognostic indicator in allogeneic hematopoietic stem cell transplantation. Blood 121:840-8,2013.


Yuki H, Ueno S, Tatetsu H, Niiro H, Iino T, Endo S, Kawano Y, Komohara Y, Takeya M, Hata H, Okada S, Watanabe T, Akashi K, Mitsuya H, Okuno Y.PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma cells. Blood 121:962-70,2013.


Saito Y, Yuki H, Kuratani M, Hashizume Y, Takagi S, Honma T, Tanaka A, Shirouzu M, Mikuni J, Handa N, Ogahara I, Sone A, Najima Y, Tomabechi Y, Wakiyama M, Uchida N, Tomizawa-Murasawa M, Kaneko A, Tanaka S, Suzuki N, Kajita H, Aoki Y, Ohara O, Shultz LD, Fukami T, Goto T, Taniguchi S, Yokoyama S, Ishikawa F.A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo. Sci Transl Med 5:181ra52,2013.


Mitoma H, Hanabuchi S, Kim T, Bao M, Zhang Z, Sugimoto N, Liu YJ.The DHX33 RNA helicase senses cytosolic RNA and activates the NLRP3 inflammasome. Immunity  39:123-35,2013.


Kunisaki Y, Bruns I, Scheiermann C, Ahmed J, Pinho S, Zhang D, Mizoguchi T, Wei Q, Lucas D, Ito K, Mar JC, Bergman A, Frenette PS.Arteriolar niches maintain haematopoietic stem cell quiescence. Nature 502:637-43,2013.


Pinho S, Lacombe J, Hanoun M, Mizoguchi T, Bruns I, Kunisaki Y, Frenette PS.PDGFRα and CD51 mark human nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion. J Exp Med 210:1351-67,2013.


Lucas D, Scheiermann C, Chow A, Kunisaki Y, Bruns I, Barrick C, Tessarollo L, Frenette PS.Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration. Nat Med 19:695-703,2013.


Scheiermann C, Kunisaki Y, Frenette PS.Circadian control of the immune system. Nat Rev Immunol 13:190-8,2013.


Shibata W, Ariyama H, Westphalen CB, Worthley DL, Muthupalani S, Asfaha S, Dubeykovskaya Z, Quante M, Fox JG, Wang TC.Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors. Gut 62:192-200,2013.


2012年

Kuriyama T, Takenaka K, Kohno K, Yamauchi T, Daitoku S, Yoshimoto G, Kikushige Y, Kishimoto J, Abe Y, Harada N, Miyamoto T, Iwasaki H, Teshima T, Akashi K.Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis. Blood 120:4058-67,2012.


Harada A, Okada S, Konno D, Odawara J, Yoshimi T, Yoshimura S, Kumamaru H, Saiwai H, Tsubota T, Kurumizaka H, Akashi K, Tachibana T, Imbalzano AN, Ohkawa Y.Chd2 interacts with H3.3 to determine myogenic cell fate. EMBO J 31:2994-3007,2012.


Niiro H, Jabbarzadeh-Tabrizi S, Kikushige Y, Shima T, Noda K, Ota S, Tsuzuki H, Inoue Y, Arinobu Y, Iwasaki H, Shimoda S, Baba E, Tsukamoto H, Horiuchi T, Taniyama T, Akashi K.CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells. Blood 119:2263-73,2012.


Kumamaru H, Ohkawa Y, Saiwai H, Yamada H, Kubota K, Kobayakawa K, Akashi K, Okano H, Iwamoto Y, Okada S.Direct isolation and RNA-seq reveal environment-dependent properties of engrafted neural stem/progenitor cells. Nat Commun 3:1140,2012.


Scheiermann C, Kunisaki Y, Lucas D, Chow A, Jang JE, Zhang D, Hashimoto D, Merad M, Frenette PS.Adrenergic nerves govern circadian leukocyte recruitment to tissues. Immunity 37:290-301,2012.


Kunisaki Y, Frenette PS.The secrets of the bone marrow niche: Enigmatic niche brings challenge for HSC expansion. Nat Med 18:864-5,2012.


Lucas D, Bruns I, Battista M, Mendez-Ferrer S, Magnon C, Kunisaki Y, Frenette PS.Norepinephrine reuptake inhibition promotes mobilization in mice: potential impact to rescue low stem cell yields. Blood 119:3962-5,2012.


2011年

Kikushige Y, Ishikawa F, Miyamoto T, Shima T, Urata S, Yoshimoto G, Mori Y, Iino T, Yamauchi T, Eto T, Niiro H, Iwasaki H, Takenaka K, Akashi K.Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia. Cancer Cell 20:246-59,2011.


Takashima S, Kadowaki M, Aoyama K, Koyama M, Oshima T, Tomizuka K, Akashi K, Teshima T.The Wnt agonist R-spondin1 regulates systemic graft-versus-host disease by protecting intestinal stem cells. J Exp Med 208:285-94,2011.


Hashimoto D, Chow A, Greter M, Saenger Y, Kwan WH, Leboeuf M, Ginhoux F, Ochando JC, Kunisaki Y, van Rooijen N, Liu C, Teshima T, Heeger PS, Stanley ER, Frenette PS, Merad M.Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation. J Exp Med  208:1069-82,2011.


Eppert K, Takenaka K, Lechman ER, Waldron L, Nilsson B, van Galen P, Metzeler KH, Poeppl A, Ling V, Beyene J, Canty AJ, Danska JS, Bohlander SK, Buske C, Minden MD, Golub TR, Jurisica I, Ebert BL, Dick JE.Stem cell gene expression programs influence clinical outcome in human leukemia. Nat Med 17:1086-93,2011.


Shimoda S, Harada K, Niiro H, Shirabe K, Taketomi A, Maehara Y, Tsuneyama K, Nakanuma Y, Leung P, Ansari AA, Gershwin ME, Akashi K.Interaction between Toll-like receptors and natural killer cells in the destruction of bile ducts in primary biliary cirrhosis. Hepatology 53:1270-81,2011.


Hashimoto D, Chow A, Greter M, Saenger Y, Kwan WH, Leboeuf M, Ginhoux F, Ochando JC, Kunisaki Y, van Rooijen N, Liu C, Teshima T, Heeger PS, Stanley ER, Frenette PS, Merad M.Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation. J Exp Med 208:1069-82,2011.


2010年

Kikushige Y, Shima T, Takayanagi S, Urata S, Miyamoto T, Iwasaki H, Takenaka K, Teshima T, Tanaka T, Inagaki Y, Akashi K.TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cells. Cell Stem Cell 7:708-17,2010.


Asakura S, Hashimoto D, Takashima S, Sugiyama H, Maeda Y, Akashi K, Tanimoto M, Teshima T.Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice. J Clin Invest 120:2370-8,2010.


Shimoda S, Harada K, Niiro H, Taketomi A, Maehara Y, Tsuneyama K, Kikuchi K, Nakanuma Y, Mackay IR, Gershwin ME, Akashi K.CX3CL1 (fractalkine): a signpost for biliary inflammation in primary biliary cirrhosis. Hepatology 51:567-75,2010.


2009年

Kalaszczynska I, Geng Y, Iino T, Mizuno S, Choi Y, Kondratiuk I, Silver DP, Wolgemuth DJ, Akashi K, Sicinski P.Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. Cell 138:352-65,2009.


Mori Y, Iwasaki H, Kohno K, Yoshimoto G, Kikushige Y, Okeda A, Uike N, Niiro H, Takenaka K, Nagafuji K, Miyamoto T, Harada M, Takatsu K, Akashi K.Identification of the human eosinophil lineage-committed progenitor: revision of phenotypic definition of the human common myeloid progenitor. J Exp Med 206:183-93,2009.


Ozaki K, Sato H, Inoue K, Tsunoda T, Sakata Y, Mizuno H, Lin TH, Miyamoto Y, Aoki A, Onouchi Y, Sheu SH, Ikegawa S, Odashiro K, Nobuyoshi M, Juo SH, Hori M, Nakamura Y, Tanaka T.SNPs in BRAP associated with risk of myocardial infarction in Asian populations. Nat Genet 41:329-33,2009.


Yoshimoto G, Miyamoto T, Siamak JT, Iino T, Rocnik JL, Kikushige Y, Mori Y, Shima T, Iwasaki H, Takenaka K, Nagafuji K, Mizuno S, Niiro H, Gilliland GD, K Akashi.FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD–specific STAT5 activation. Blood 114:5034-43,2009.


Koyama M, Hashimoto D, Aoyama K, Matsuoka K, Karube K, Niiro H, Harada M, Tanimoto M, Akashi K, Teshima T.Plasmacytoid dendritic cells prime alloreactive T cells to mediate graft-versus-host disease as antigen-presenting cells. Blood 113:2088-95,2009.


Aoyama K, Koyama M, Matsuoka K, Hashimoto D, Ichinohe T, Harada M, Akashi K, Tanimoto M, Teshima T.Improved outcome of allogeneic bone marrow transplantation due to breastfeeding-induced tolerance to maternal antigens. Blood 113:1829-33,2009.


2008年

Cantor AB, Iwasaki H, Arinobu Y, Moran TB, Shigematsu H, Sullivan MR, Akashi K, Orkin SH.Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. J Exp Med 205:611-24,2008.


Shimoda S, Harada K, Niiro H, Yoshizumi T, Soejima Y, Taketomi A, Maehara Y, Tsuneyama K, Nakamura M, Komori A, Migita K, Nakanuma Y, Ishibashi H, Selmi C, Gershwin ME.Biliary epithelial cells and primary biliary cirrhosis: the role of liver-infiltrating mononuclear cells. Hepatology 47:958-65,2008.


2007年

Ishikawa F, Yoshida S, Saito Y, Hijikata A, Kitamura H, Tanaka S, Nakamura R, Tanaka T, Tomiyama H, Saito N, Fukata M, Miyamoto T, Lyons B, Ohshima K, Uchida N, Taniguchi S, Ohara O, Akashi K, Harada M, Shultz LD.Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotechnol 25:1315-21,2007.


Takenaka K, Prasolava TK, Wang JC, Mortin-Toth SM, Khalouei S, Gan OI, Dick JE, Danska JS.Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells. Nat Immunol 8:1313-23,2007.


Iwasaki H, Akashi K.Myeloid lineage commitment from the hematopoietic stem cell. Immunity 26:726-40,2007.


Arinobu Y, Mizuno S, Chong Y, Shigematsu H, Iino T, Iwasaki H, Graf T, Mayfield R, Chan S, Kastner P, Akashi K.Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages. Cell Stem Cell 1:416-27,2007.


Sakoda Y, Hashimoto D, Asakura S, Takeuchi K, Harada M, Tanimoto M, Teshima T.Donor-derived thymic-dependent T cells cause chronic graft-versus-host disease. Blood 109:1756-64,2007.


Ishikawa F, Niiro H, Iino T, Yoshida S, Saito N, Onohara S, Miyamoto T, Minagawa H, Fujii S, Shultz LD, Harada M, Akashi K.The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways.Blood 110:3591-660,2007.


2006年

Iwasaki H, Mizuno S, Arinobu Y, Ozawa H, Mori Y, Shigematsu H, Takatsu K, Tenen DG, Akashi K.The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages. Genes Dev 20:3010-21,2006.


Rosenbauer F, Owens BM, Yu L, Tumang JR, Steidl U, Kutok JL, Clayton LK, Wagner K, Scheller M, Iwasaki H, Liu C, Hackanson B, Akashi K, Leutz A, Rothstein TL, Plass C, Tenen DG.Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1. Nat Genet 38:27-37,2006.


Hirai H, Zhang P, Dayaram T, Hetherington CJ, Mizuno S, Imanishi J, Akashi K, Tenen DG.C/EBPbeta is required for 'emergency' granulopoiesis. Nat Immunol 7:732-9,2006.


Shimoda S, Ishikawa F, Kamihira T, Komori A, Niiro H, Baba E, Harada K, Isse K, Nakanuma Y, Ishibashi H, Gershwin ME, Harada M.Autoreactive T-cell responses in primary biliary cirrhosis are proinflammatory whereas those of controls are regulatory. Gastroenterology 131:606-18,2006.


Iwasaki H, Akashi K.Thymus exclusivity: all the right conditions for T cells. Immunity 25:697-700,2006.


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